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| Public Evening: Familial Bowel Cancer Syndromes - an update and international perspective |
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| 1900 - 1930 | Registration and tea/coffee | |
| 1930 - 1935 | Welcome Susan Parry |
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| 1935 - 1940 | Cancer Society Auckland/Northland Alistair Burry |
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| 1940 - 1955 | Update on diagnosis and management Patrick Lynch |
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| 1955 - 2025 | Panel: What is happening in other countries? Ian Frayling, Nicoline Hoogerbrugge, Finlay Macrae |
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| 2025 - 2030 | What is happening in New Zealand? Julie Arnold |
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| 2030 - 2100 | Discussion | |
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Patrick LynchPatrick Lynch is Professor of Medicine, Department of Gastroenterology, Hepatology, Nutrition, University of Texas MD Anderson Cancer Centre. He has been a member of InSiGHT since its inception and was Co-chair 2009-11. He was a member of the predecessor organisations, the LCPG and ICG-HNPCC. His current interest is the development of a web-based platform for communication of risk information within mutation-positive families. He ran the 2016 New York Marathon to raise funds for InSiGHT. |
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Ian FraylingIan qualified in Clinical Medicine at Cambridge. After initial training in all branches of pathology, he studied DNA repair for his PhD. He is the only Genetic Pathologist in NHS service, at the Institute of Medical Genetics, Cardiff.Ian was the Family Cancer Clinic Research Fellow at St Mark's Hospital, 1993-1998. He now concentrates on variant interpretation, genotype-phenotype correlations and systematic testing of incident cancers to identify hereditary cases. He is a Fellow of the Royal College of Pathologists, a UK National External Quality Assessor of MMR IHC, an Honorary Senior Clinical Research Fellow at Cardiff University, and a Visiting CI at Cancer Council New South Wales. He is a co-author on the upcoming 5th Edition of the WHO/IARC Classification of Tumours "Blue Books" series. (orcid.org/0000-0002-3420-0794) Ian is also a member of InSiGHT Council and the Variant Interpretation Committee; a member of CGAICC; the steering group of the Prospective Lynch Syndrome Database; an Honorary Medical Adviser to Lynch Syndrome UK; and Treasurer of the UK Cancer Genetics Group, inter alia. In 2017, Ian was conferred with Honorary Fellowship of the Faculty of Pathology of the Royal College of Physicians of Ireland in recognition of his outstanding lifetime contribution to the practice of pathology and received the Association of Clinical Pathologists' Dyke Foundation Medal. He will deliver the Goudie Medal lecture in January 2019 at the Pathological Society's Winter Meeting. |
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Nicoline HoogerbruggeProf Nicoline Hoogerbrugge, MD, PhD, is Over the last 5 years, her work has mainly focused on the implementation of current knowledge in hereditary cancer and finding new genetic factors for gastrointestinal cancer. Her research in the past 5 years resulted in:
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Finlay MacraeFinlay Macrae is Professor in the Department of Medicine, University of Melbourne, Australia and Head of Colorectal Medicine and Genetics at The Royal Melbourne Hospital. He was a founding member of the antecedent Leeds Castle Polyposis |
| 0830 - 0835 | Official opening - Mihi Whakatau | |
| 0835 - 0840 | Official opening Ashley Bloomfield, Director General of Health |
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0840 - 0845 |
Official opening |
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0845 - 0900 |
Chair: Susan Parry, Maurizio Genuardi KAY NEALE LECTURE Gastrointestinal hereditary tumours: What we know and what we need to know? |
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| 0900 - 0920 | Cancer risks associated with MMR gene mutations - how can we define further? Mark Jenkins |
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| 0920 - 0950 | Chair: Allan Spigelman, Maurizio Genuardi Free papers - 5 minutes each followed by 10 minutes discussion Cancer risks by age and gender in carriers of pathogenic MMR variants: Findings from the Prospective Lynch Syndrome Database (PLSD) report Mev Dominguez Valentin Breast cancer risk not increased in women with Lynch Syndrome identified by multi-gene panel testing Sonia Kupfer Effective triage of sebaceous neoplasia for Lynch Syndrome Ingrid Winship Sanne Ten Broeke |
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| 0950 - 1030 | Free papers - 5 minutes each followed by 15 minutes discussion Molecular tumour testing in Lynch-like patients reveals de nono mosaic DNA mismatch repair gene pathogenic variants transmitted to offspring Chrystelle Colas Predictors of class: Using protein structure and function information to predict and understand mismatch repair variant pathogenicity Bernard Pope cDNA analyses of the MMR genes MLH1, MSH2, MSH6 and PMS2 investigate the effect of VUS upon splicing, detect unexpected splicing defects, and find allelic losses indicating a germline defect Elke Holinski-Feder Highly sensitive MLH1 methylation analysis in blood identifies a cancer patient with low-level mosaic MLH1 epimutation Gabriel Capella Comprehensive constitutional genetic and epigenetic characterization of Lynch-like individuals Gabriel Capella |
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1030 - 1100 |
Morning Tea |
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1100 - 1125 |
Chair: Patrick Lynch, Nicoline Hoogerbrugge HENRY LYNCH LECTURE Finding people at risk of Lynch Syndrome |
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| 1125 - 1200 | Free papers - 5 minutes each followed by 15 minutes discussion Reflex Mis-Match-Deficiency testing of colorectal cancer below age 70 to detect Lynch Syndrome: A prospective, multicenter, multidisciplinary evaluation of uptake, yield and appreciation Nicoline Hoogerbrugge UK National External Quality Assessment Scheme for Immunocytochemistry and In Situ Hybridisation: 10 years of international experience with mismatch repair proteins shows that participation improves performance Ian Frayling Evaluating tumour mutational signatures for classification of mismatch repair deficiency and identification of Lynch syndrome and MLH1 methylated subtypes Peter Georgeson RAID-LS: A non-invasive tool based on Joan Brunet |
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| 1200 - 1215 | Free papers - 5 minutes each followed by 5 minutes discussion Multiple Genetic Tumor Syndromes: When to suspect them? Maurizio Genuardi Germline pathogenic variants of hereditary cancer genes in 12,347 colorectal cancer patients and 27,706 controls in Hidewaki Nakagawa |
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| 1215 - 1230 | Somatic mutations in colorectal cancer and implications for genetic testing Gabriel Capella |
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1230 - 1325 |
Lunch Break |
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| 1325 - 1350 | Chair: Magnus von Knebel Doeberitz, Ian Frayling The immune system in Lynch Syndrome/hereditary colorectal cancer Magnus von Knebel Doeberitz |
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| 1350 - 1430 | Free papers - 5 minutes each followed by 15 minutes discussion The shared mutation and neoantigen landscape of MMR-deficient cancers suggests immunoediting during Alexej Ballhausen High endothelial venules are associated with immune evasion and hereditary background in microsatellite-unstable colorectal cancers Aysel Germline variants associated with immune infiltration in solid Sahar Shahamatdar Intratumoural assessment of colorectal cancer diagnostic and prognostic markers using RNA in situ hybridization Tim Eglinton A mouse model for a vaccine against Lynch Syndrome-associated cancers Matthias Kloor |
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| 1430 - 1445 | Chair: Ian Frayling, Ben Lawrence Free papers - 5 minutes each followed by 5 minutes discussion Genetic Cancer Susceptibility in Adolescents and Young Adults with Colorectal Cancer Therapy-associated polyposis in childhood and young Matthew Yurgelun |
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| 1445 - 1510 | Update on targeted therapies in Gastrointestinal Oncology Michael Hall |
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1510 - 1540 |
Afternoon Tea |
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1540 - 1605 |
Chair: Parry Guilford, Ingrid Winship Hereditary Diffuse Gastric Cancer (HDGC) - past, present, future |
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1605 - 1615 |
Genetic counselling in HDGC - the bi-cultural context |
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1615 - 1630 |
Challenges in genetic counselling - case discussions |
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| 1630 - 1655 | Free papers - 5 minutes each followed by 10 minutes discussion Early Genetic Counseling and Detection of CDH1 Mutation in Asymptomatic Carriers Improves Survival in Hereditary Diffuse Gastro Cancer R Matthew Walsh CDH1 Gastric Cancer: Does Family History Change Your Risk? Margaret O'Malley Multiple-gene panel analysis in an Italian cohort of patients with familial gastric cancer Gianluca Tedaldi |
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| 1655 - 1710 | Chair: Parry Guilford, Susan Parry Gastroscopy in HDGC - an update Massimiliano Di Pietro |
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| 1710 - 1725 | Free papers - 5 minutes each followed by 5 minutes discussion Technical and Endoscopic Factors in CDH1 gastric cancer surveillance Carol Burke Gastroscopic outcomes compared with histology in CDH1 mutation carriers; 9 years experience with the International Gastric Cancer Linkage Consortium Consensus Guideline Jolanda van Dieren |
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| 1725 - 1740 | Guideline update - hot news from Wanaka Nicoline Hoogerbrugge |
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| 1800 - 2000 | Welcome Reception - Maritime Museum | |
| 2000 | Council Dinner | |
Rachel Cook
Conference Innovators
P: +64 9 525 2464
E: rachel@conference.co.nz
